The combination of amoxycillin and colistin has additional antibacterial action. Amoxycillin is a semi-synthetic broad-spectrum penicillin with bactericidal action against Gram-positive and Gram-negative bacteria. The action is based on inhibition of the bacterial cell wall formation through interference of the muco-peptide synthesis. Susceptible bacteria for this formulation are Streptococci, penicillinase negative Staphylococci, Haemophilus spp., Corynebacterium spp., Brucella spp., Shigella spp., Fusiformis spp., Clostridium spp., Spherophorus necrophorus and Erysipelothrix.
Colistin, a cyclic poly-peptide antibiotic has bacterial action against selected Gram-negative bacteria. The primary bacterial effect of colistin is a blockade of the cell division of bacteria followed by secondary progressive lysis. Susceptible bacteria are Aerobacter aerogenes, Escherichia coli, Salmonella spp., Shigella spp., Haemophilus spp., Pasteurella spp., Pseudomonas aeruginosa, Vibrio spp., and Paracolon bacteria.
INDICATIONS:
COLIMOX Inj. is effective against infections caused by bacteria susceptible to the combination of amoxycillin and colistin, like respiratory, gastrointestinal, and urogenital infections and secondary bacterial infections during the course of viral diseases in cattle, calves and pigs.
CONTRA-INDICATIONS:
Do not administer to small herbivores, other animals than recommended, animals with serious renal disturbances, newborns.
SIDE EFFECTS:
Local irritation has been noticed at the injection site in cattle and pigs.
Prolonged administration of higher than recommended doses may result in kidney damage (due to colistin) and normally reversible neurotoxic symptoms.
INCOMPATIBILITY WITH OTHER DRUGS:
Simultaneous administration with fast-acting bacteriostatic antibiotics (like tetracycline) should be avoided. Do not mix or dilute this product with water or other solvents.
DOSAGE AND ADMINISTRATION:
For intramuscular injection only. Shake well before use.
General dose : 1 ml per 10 kg bodyweight, once daily.
This dose may be repeated for 3 consecutive days.
No more than 20 ml should be injected into a single site.
WITHDRAWAL PERIOD:
Edible tissues : 21 days
Milk : 3 days
STORAGE:
Store in a dry, dark place between 15 °C and 25 °C.
Keep medicine away from children.
